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TOPLINE:Shared inflammatory signatures in vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, myelodysplasia cutis (MDS-cutis), and Sweet syndrome (SS) suggest interferon pathways as therapeutic targets. METHODOLOGY:Multicenter translational study in France compared 20 patients with cutaneous lesions (median age 67 years; 50% men) with five healthy control skin samples.Lesion types were VEXAS syndrome, MDS-cutis, idiopathic SS, […] More

ORLANDO, Fla. — The interleukin (IL)-4 and IL-13 inhibitor dupilumab improved itch symptoms and curtailed disease activity while also reducing oral corticosteroid use in older patients with bullous pemphigoid (BP), a phase 2/3 study demonstrated. “Dupilumab demonstrated significant benefits across multiple disease aspects in BP at 36 weeks, including achieving sustained remission at week 36 […] More